Site‐Specific Hyperphosphorylation Inhibits, Rather than Promotes, Tau Fibrillization, Seeding Capacity, and Its Microtubule Binding

The consistent observation of phosphorylated tau in the pathology of Alzheimer's disease has contributed to the emergence of a model where hyperphosphorylation triggers both tau disassociation from microtubules and its subsequent aggregation. Herein, we applied a total chemical synthetic approa...

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Detalles Bibliográficos
Autores principales: Haj‐Yahya, Mahmood, Gopinath, Pushparathinam, Rajasekhar, Kolla, Mirbaha, Hilda, Diamond, Marc I., Lashuel, Hilal A.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: John Wiley and Sons Inc. 2020
Materias:
Research Articles
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065254/
https://www.ncbi.nlm.nih.gov/pubmed/31863676
http://dx.doi.org/10.1002/anie.201913001

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065254/
https://www.ncbi.nlm.nih.gov/pubmed/31863676
http://dx.doi.org/10.1002/anie.201913001

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