Amoxicillin Inactivation by Thiol-Catalyzed Cyclization Reduces Protein Haptenation and Antibacterial Potency

Serum and cellular proteins are targets for the formation of adducts with the β-lactam antibiotic amoxicillin. This process could be important for the development of adverse, and in particular, allergic reactions to this antibiotic. In studies exploring protein haptenation by amoxicillin, we observe...

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Detalles Bibliográficos
Autores principales: Pajares, María A., Zimmerman, Tahl, Sánchez-Gómez, Francisco J., Ariza, Adriana, Torres, María J., Blanca, Miguel, Cañada, F. Javier, Montañez, María I., Pérez-Sala, Dolores
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065267/
https://www.ncbi.nlm.nih.gov/pubmed/32210804
http://dx.doi.org/10.3389/fphar.2020.00189

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065267/
https://www.ncbi.nlm.nih.gov/pubmed/32210804
http://dx.doi.org/10.3389/fphar.2020.00189

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