Preclinical studies on the toxicology, pharmacokinetics and safety of K1-70(TM) a human monoclonal autoantibody to the TSH receptor with TSH antagonist activity

BACKGROUND: The human monoclonal autoantibody K1-70™ binds to the TSH receptor (TSHR) with high affinity and blocks TSHR cyclic AMP stimulation by TSH and thyroid stimulating autoantibodies. METHODS: The preclinical toxicology assessment following weekly intravenous (IV) or intramuscular (IM) admini...

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Detalles Bibliográficos
Autores principales: Furmaniak, Jadwiga, Sanders, Jane, Clark, Jill, Wilmot, Jane, Sanders, Paul, Li, Yang, Rees Smith, Bernard
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065368/
https://www.ncbi.nlm.nih.gov/pubmed/32257067
http://dx.doi.org/10.1186/s13317-019-0121-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065368/
https://www.ncbi.nlm.nih.gov/pubmed/32257067
http://dx.doi.org/10.1186/s13317-019-0121-9

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