Proton Nuclear Magnetic Resonance Metabolomics Corroborates Serine Hydroxymethyltransferase as the Primary Target of 2-Aminoacrylate in a ridA Mutant of Salmonella enterica

The reactive intermediate deaminase RidA (EC 3.5.99.10) is conserved across all domains of life and deaminates reactive enamine species. When Salmonella enterica ridA mutants are grown in minimal medium, 2-aminoacrylate (2AA) accumulates, damages several pyridoxal 5′-phosphate (PLP)-dependent enzyme...

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Detalles Bibliográficos
Autores principales: Borchert, Andrew J., Gouveia, Goncalo J., Edison, Arthur S., Downs, Diana M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Society for Microbiology 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065518/
https://www.ncbi.nlm.nih.gov/pubmed/32156800
http://dx.doi.org/10.1128/mSystems.00843-19

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065518/
https://www.ncbi.nlm.nih.gov/pubmed/32156800
http://dx.doi.org/10.1128/mSystems.00843-19

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