Intranasal administration of dantrolene increased brain concentration and duration

Dantrolene has been demonstrated to be neuroprotective for multiple neurodegenerative diseases. However, dantrolene’s limited penetration into the CNS hampers its effectiveness as a neuroprotective agent. Here, we studied whether the intranasal administration of dantrolene provided better penetratio...

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Detalles Bibliográficos
Autores principales: Wang, Jintao, Shi, Yun, Yu, Shuchun, Wang, Yan, Meng, Qingcheng, Liang, Ge, Eckenhoff, Maryellen F., Wei, Huafeng
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065741/
https://www.ncbi.nlm.nih.gov/pubmed/32160210
http://dx.doi.org/10.1371/journal.pone.0229156

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065741/
https://www.ncbi.nlm.nih.gov/pubmed/32160210
http://dx.doi.org/10.1371/journal.pone.0229156

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