Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

Parkinson’s disease (PD) is a synucleinopathy that is characterized by motor dysfunction, death of midbrain dopaminergic neurons, and accumulation of alpha synuclein (α-Syn) aggregates. Evidence suggests that α-Syn aggregation can originate in peripheral tissues and progress to the brain via autonom...

Descripción completa

Detalles Bibliográficos
Autores principales: Challis, Collin, Hori, Acacia, Sampson, Timothy R., Yoo, Bryan B., Challis, Rosemary C., Hamilton, Adam M., Mazmanian, Sarkis K., Volpicelli-Daley, Laura A., Gradinaru, Viviana
Formato: Online Artículo Texto
Lenguaje:English
Publicado: 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065967/
https://www.ncbi.nlm.nih.gov/pubmed/32066981
http://dx.doi.org/10.1038/s41593-020-0589-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065967/
https://www.ncbi.nlm.nih.gov/pubmed/32066981
http://dx.doi.org/10.1038/s41593-020-0589-7

Ejemplares similares