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Gut-seeded α-synuclein fibrils promote gut dysfunction and brain pathology specifically in aged mice

Parkinson’s disease (PD) is a synucleinopathy that is characterized by motor dysfunction, death of midbrain dopaminergic neurons, and accumulation of alpha synuclein (α-Syn) aggregates. Evidence suggests that α-Syn aggregation can originate in peripheral tissues and progress to the brain via autonom...

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Detalles Bibliográficos
Autores principales:	Challis, Collin, Hori, Acacia, Sampson, Timothy R., Yoo, Bryan B., Challis, Rosemary C., Hamilton, Adam M., Mazmanian, Sarkis K., Volpicelli-Daley, Laura A., Gradinaru, Viviana
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7065967/ https://www.ncbi.nlm.nih.gov/pubmed/32066981 http://dx.doi.org/10.1038/s41593-020-0589-7

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