Redox-sensitive, PEG-shielded carboxymethyl PEI nanogels silencing MicroRNA-21, sensitizes resistant ovarian cancer cells to cisplatin

A series of branched polyethylenimine (PEI) modifications including PEGylation (PEG2k-PEI) for steric shielding, redox-sensitive crosslinking for synthesis PEG2k-PEI-ss nanogels and subsequent carboxymethylation (PEG2k-CMPEI-ss) for modulation of the polymer pk(a) have been introduced for cellular d...

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Detalles Bibliográficos
Autores principales: Javanmardi, Sanaz, Tamaddon, Ali Mohammad, Aghamaali, Mahmoud Reza, Ghahramani, Ladan, Abolmaali, Samira Sadat
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Shenyang Pharmaceutical University 2020
Materias:
Original Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066047/
https://www.ncbi.nlm.nih.gov/pubmed/32175019
http://dx.doi.org/10.1016/j.ajps.2018.10.006

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066047/
https://www.ncbi.nlm.nih.gov/pubmed/32175019
http://dx.doi.org/10.1016/j.ajps.2018.10.006

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