High risk of breast cancer in women with biallelic pathogenic variants in CHEK2

PURPOSE: Compared to breast cancer risk genes such as BRCA2, ATM, PALB2, and NBN, no defined phenotype is currently associated with biallelic pathogenic variants (PVs) in CHEK2. This study compared the prevalence of breast and other cancers in women with monoallelic and biallelic CHEK2 PVs. METHODS:...

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Detalles Bibliográficos
Autores principales: Rainville, Irene, Hatcher, Shanell, Rosenthal, Eric, Larson, Katie, Bernhisel, Ryan, Meek, Stephanie, Gorringe, Heidi, Mundt, Erin, Manley, Susan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Springer US 2020
Materias:
Brief Report
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066089/
https://www.ncbi.nlm.nih.gov/pubmed/31993860
http://dx.doi.org/10.1007/s10549-020-05543-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066089/
https://www.ncbi.nlm.nih.gov/pubmed/31993860
http://dx.doi.org/10.1007/s10549-020-05543-3

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