Endothelial-specific Loss of IFT88 Promotes Endothelial-to-Mesenchymal Transition and Exacerbates Bleomycin-induced Pulmonary Fibrosis

Intraflagellar transport protein 88 (Ift88) is required for ciliogenesis and shear stress-induced dissolution of cilia in embryonic endothelial cells coincides with endothelial-to-mesenchymal transition (EndMT) in the developing heart. EndMT is also suggested to underlie heart and lung fibrosis, how...

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Detalles Bibliográficos
Autores principales: Singh, Shweta, Adam, Mohamed, Matkar, Pratiek N., Bugyei-Twum, Antoinette, Desjardins, Jean-Francois, Chen, Hao H., Nguyen, Hien, Bazinet, Hannah, Michels, David, Liu, Zongyi, Mebrahtu, Elizabeth, Esene, Lillian, Joseph, Jameela, Ehsan, Mehroz, Qadura, Mohammad, Connelly, Kim A., Leong-Poi, Howard, Singh, Krishna K.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066128/
https://www.ncbi.nlm.nih.gov/pubmed/32161282
http://dx.doi.org/10.1038/s41598-020-61292-9

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066128/
https://www.ncbi.nlm.nih.gov/pubmed/32161282
http://dx.doi.org/10.1038/s41598-020-61292-9

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