NBEAL1 controls SREBP2 processing and cholesterol metabolism and is a susceptibility locus for coronary artery disease

Dysregulated cholesterol homeostasis promotes the pathology of atherosclerosis, myocardial infarction and strokes. Cellular cholesterol is mainly regulated at the transcriptional level by SREBP2, but also through uptake of extracellular cholesterol from low density lipoproteins (LDL) via expression...

Descripción completa

Detalles Bibliográficos
Autores principales: Bindesbøll, Christian, Aas, Aleksander, Ogmundsdottir, Margret Helga, Pankiv, Serhiy, Reine, Trine, Zoncu, Roberto, Simonsen, Anne
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066131/
https://www.ncbi.nlm.nih.gov/pubmed/32161285
http://dx.doi.org/10.1038/s41598-020-61352-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066131/
https://www.ncbi.nlm.nih.gov/pubmed/32161285
http://dx.doi.org/10.1038/s41598-020-61352-0

Ejemplares similares