Physiological significance of proteolytic processing of Reelin revealed by cleavage-resistant Reelin knock-in mice

Reelin is a secreted protein that plays versatile roles in neuronal development and function. The strength of Reelin signaling is regulated by proteolytic processing, but its importance in vivo is not yet fully understood. Here, we generated Reelin knock-in (PA-DV KI) mice in which the key cleavage...

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Detalles Bibliográficos
Autores principales: Okugawa, Eisuke, Ogino, Himari, Shigenobu, Tomofumi, Yamakage, Yuko, Tsuiji, Hitomi, Oishi, Hisashi, Kohno, Takao, Hattori, Mitsuharu
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066138/
https://www.ncbi.nlm.nih.gov/pubmed/32161359
http://dx.doi.org/10.1038/s41598-020-61380-w

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066138/
https://www.ncbi.nlm.nih.gov/pubmed/32161359
http://dx.doi.org/10.1038/s41598-020-61380-w

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