Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy

Cancer chemotherapy targeting frequent loss of heterozygosity events is an attractive concept, since tumor cells may lack enzymatic activities present in normal constitutional cells. To find exploitable targets, we map prevalent genetic polymorphisms to protein structures and identify 45 nsSNVs (non...

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Detalles Bibliográficos
Autores principales: Rendo, Veronica, Stoimenov, Ivaylo, Mateus, André, Sjöberg, Elin, Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Ng, Adrian, OʼBrien, Casey, Giannakis, Marios, Artursson, Per, Nygren, Peter, Cheong, Ian, Sjöblom, Tobias
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066191/
https://www.ncbi.nlm.nih.gov/pubmed/32161261
http://dx.doi.org/10.1038/s41467-020-15111-4

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066191/
https://www.ncbi.nlm.nih.gov/pubmed/32161261
http://dx.doi.org/10.1038/s41467-020-15111-4

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