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Exploiting loss of heterozygosity for allele-selective colorectal cancer chemotherapy
Cancer chemotherapy targeting frequent loss of heterozygosity events is an attractive concept, since tumor cells may lack enzymatic activities present in normal constitutional cells. To find exploitable targets, we map prevalent genetic polymorphisms to protein structures and identify 45 nsSNVs (non...
Autores principales: | Rendo, Veronica, Stoimenov, Ivaylo, Mateus, André, Sjöberg, Elin, Svensson, Richard, Gustavsson, Anna-Lena, Johansson, Lars, Ng, Adrian, OʼBrien, Casey, Giannakis, Marios, Artursson, Per, Nygren, Peter, Cheong, Ian, Sjöblom, Tobias |
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Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
Nature Publishing Group UK
2020
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Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066191/ https://www.ncbi.nlm.nih.gov/pubmed/32161261 http://dx.doi.org/10.1038/s41467-020-15111-4 |
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