Increasing Tau 4R Tau Levels Exacerbates Hippocampal Tau Hyperphosphorylation in the hTau Model of Tauopathy but Also Tau Dephosphorylation Following Acute Systemic Inflammation

Inflammation is considered a mechanistic driver of Alzheimer's disease, thought to increase tau phosphorylation, the first step to the formation of neurofibrillary tangles (NFTs). To further understand how inflammation impacts the development of tau pathology, we used (hTau) mice, which express...

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Detalles Bibliográficos
Autores principales: Barron, Matthew R., Gartlon, Jane, Dawson, Lee A., Atkinson, Peter J., Pardon, Marie-Christine
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Immunology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066213/
https://www.ncbi.nlm.nih.gov/pubmed/32194553
http://dx.doi.org/10.3389/fimmu.2020.00293

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066213/
https://www.ncbi.nlm.nih.gov/pubmed/32194553
http://dx.doi.org/10.3389/fimmu.2020.00293

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