Beyond hemostasis: a snake venom serine protease with potassium channel blocking and potential antitumor activities

Snake venom serine proteases (SVSPs) are complex and multifunctional enzymes, acting primarily on hemostasis. In this work, we report the hitherto unknown inhibitory effect of a SVSP, named collinein-1, isolated from the venom of Crotalus durissus collilineatus, on a cancer-relevant voltage-gated po...

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Detalles Bibliográficos
Autores principales: Boldrini-França, Johara, Pinheiro-Junior, Ernesto Lopes, Peigneur, Steve, Pucca, Manuela Berto, Cerni, Felipe Augusto, Borges, Rafael Junqueira, Costa, Tássia Rafaella, Carone, Sante Emmanuel Imai, Fontes, Marcos Roberto de Mattos, Sampaio, Suely Vilela, Arantes, Eliane Candiani, Tytgat, Jan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066243/
https://www.ncbi.nlm.nih.gov/pubmed/32161292
http://dx.doi.org/10.1038/s41598-020-61258-x

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066243/
https://www.ncbi.nlm.nih.gov/pubmed/32161292
http://dx.doi.org/10.1038/s41598-020-61258-x

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