Inhibition of Myostatin Reduces Collagen Deposition in a Mouse Model of Oculopharyngeal Muscular Dystrophy (OPMD) With Established Disease

BACKGROUND: Oculopharyngeal muscular dystrophy (OPMD) is a late-onset muscle disease presented by ptosis, dysphagia, and limb weakness. Affected muscles display increased fibrosis and atrophy, with characteristic inclusion bodies in the nucleus. Myostatin is a negative regulator of muscle mass, and...

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Detalles Bibliográficos
Autores principales: Harish, Pradeep, Forrest, Leysa, Herath, Shanti, Dickson, George, Malerba, Alberto, Popplewell, Linda
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Physiology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066371/
https://www.ncbi.nlm.nih.gov/pubmed/32194441
http://dx.doi.org/10.3389/fphys.2020.00184

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066371/
https://www.ncbi.nlm.nih.gov/pubmed/32194441
http://dx.doi.org/10.3389/fphys.2020.00184

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