Functional Selectivity and Antinociceptive Effects of a Novel KOPr Agonist

Kappa opioid receptor (KOPr) agonists represent alternative analgesics for their low abuse potential, although relevant adverse effects have limited their clinical use. Functionally selective KOPr agonists may activate, in a pathway-specific manner, G protein-mediated signaling, that produces antino...

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Detalles Bibliográficos
Autores principales: Bedini, Andrea, Di Cesare Mannelli, Lorenzo, Micheli, Laura, Baiula, Monica, Vaca, Gabriela, De Marco, Rossella, Gentilucci, Luca, Ghelardini, Carla, Spampinato, Santi
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Pharmacology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066533/
https://www.ncbi.nlm.nih.gov/pubmed/32210803
http://dx.doi.org/10.3389/fphar.2020.00188

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066533/
https://www.ncbi.nlm.nih.gov/pubmed/32210803
http://dx.doi.org/10.3389/fphar.2020.00188

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