Cargando…
Molecular Modeling Study of Uncharged Oximes Compared to HI-6 and 2-PAM Inside Human AChE Sarin and VX Conjugates
[Image: see text] The deleterious effects of nerve agents over the enzymes acetylcholinesterase (AChE) and butyrylcholinesterase (BChE) turned these compounds into the most dangerous chemical weapons known. Among the antidotes in use today against these agents, oximes in combination with other drugs...
Autores principales: | Souza, Felipe Rodrigues de, Rodrigues Garcia, Danielle, Cuya, Teobaldo, Pimentel, André Silva, Gonçalves, Arlan da Silva, Alencastro, Ricardo Bicca de, França, Tanos Celmar Costa |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
American Chemical Society
2020
|
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066550/ https://www.ncbi.nlm.nih.gov/pubmed/32175496 http://dx.doi.org/10.1021/acsomega.9b03737 |
Ejemplares similares
-
Molecular modeling studies on the interactions of 7-methoxytacrine-4-pyridinealdoxime, 4-PA, 2-PAM, and obidoxime with VX-inhibited human acetylcholinesterase: a near attack conformation approach
por: da Silva, Jorge Alberto Valle, et al.
Publicado: (2019) -
Toxic chemical weapons of assassination and warfare: nerve agents VX and sarin
por: Chai, Peter R., et al.
Publicado: (2017) -
New Uncharged 2-Thienostilbene Oximes as Reactivators of Organophosphate-Inhibited Cholinesterases
por: Mlakić, Milena, et al.
Publicado: (2021) -
The benefit of combinations of oximes for the ability of antidotal treatment to counteract sarin-induced brain damage in rats
por: Caisberger, Filip, et al.
Publicado: (2018) -
Discovery of Novel Non-Oxime Reactivators Showing In Vivo Antidotal Efficiency for Sarin Poisoned Mice
por: Wei, Zhao, et al.
Publicado: (2022)