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Formulation and Intracellular Trafficking of Lipid–Drug Conjugate Nanoparticles Containing a Hydrophilic Antitubercular Drug for Improved Intracellular Delivery to Human Macrophages

[Image: see text] Isoniazid is an important first-line antitubercular drug used in the treatment of all major clinical manifestations of tuberculosis, including both pulmonary and cerebral diseases. However, it is associated with significant drawbacks due to its inherent hydrophilic nature, includin...

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Detalles Bibliográficos
Autores principales: Pandit, Sayantan, Roy, Subhadeep, Pillai, Jonathan, Banerjee, Subham
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Chemical Society 2020
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066568/
https://www.ncbi.nlm.nih.gov/pubmed/32175491
http://dx.doi.org/10.1021/acsomega.9b03523