BACE2 degradation is mediated by both the proteasome and lysosome pathways

BACKGROUND: Alzheimer’s disease is the most common neurodegenerative disease in the elderly. Amyloid-β protein (Aβ) is the major component of neuritic plaques which are the hallmark of AD pathology. β-site APP cleaving enzyme 1 (BACE1) is the major β-secretase contributing to Aβ generation. β-site A...

Descripción completa

Detalles Bibliográficos
Autores principales: Qiu, Kaixin, Liang, Wenping, Wang, Shuai, Kong, Tingting, Wang, Xin, Li, Chunyan, Wang, Zhe, Wu, Yili
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066761/
https://www.ncbi.nlm.nih.gov/pubmed/32160867
http://dx.doi.org/10.1186/s12860-020-00260-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066761/
https://www.ncbi.nlm.nih.gov/pubmed/32160867
http://dx.doi.org/10.1186/s12860-020-00260-7

Ejemplares similares