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MDC1 depletion promotes cisplatin induced cell death in cervical cancer cells

OBJECTIVE: Cisplatin, the most common chemotherapeutic drug for the treatment of advanced stage cervical cancers has limitations in terms of drugs resistance observed in patients partly due to functional DNA damage repair (DDR) processes in the cell. Mediator of DNA damage checkpoint 1 (MDC1) is an...

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Detalles Bibliográficos
Autores principales: Singh, Neeru, Bhakuni, Rashmi, Chhabria, Dimple, Kirubakaran, Sivapriya
Formato: Online Artículo Texto
Lenguaje:English
Publicado: BioMed Central 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066845/
https://www.ncbi.nlm.nih.gov/pubmed/32160908
http://dx.doi.org/10.1186/s13104-020-04996-5