PKM2 suppresses osteogenesis and facilitates adipogenesis by regulating β-catenin signaling and mitochondrial fusion and fission

Bone marrow mesenchymal stem cells (BMSCs) differentiation dysfunction is a common pathological phenotype of several prevalent metabolic and genetic bone diseases. Pyruvate kinase muscle isoenzyme 2 (PKM2) regulates the last step of glycolysis, and its role in BMSCs differentiation is still unknown....

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Detalles Bibliográficos
Autores principales: Guo, Jiachao, Ren, Ranyue, Yao, Xudong, Ye, Yaping, Sun, Kai, Lin, Jiamin, Wang, Genchun, Guo, Fengjing, Xiao, Jun, Xu, Tao
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066892/
https://www.ncbi.nlm.nih.gov/pubmed/32096765
http://dx.doi.org/10.18632/aging.102866

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066892/
https://www.ncbi.nlm.nih.gov/pubmed/32096765
http://dx.doi.org/10.18632/aging.102866

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