Identification of a lathyrane-type diterpenoid EM-E-11-4 as a novel paclitaxel resistance reversing agent with multiple mechanisms of action

P-glycoprotein (P-gp) and βIII-tubulin overexpression-mediated drug resistance leads to clinical therapy failure for paclitaxel. However, the development of paclitaxel-resistance reversal agents has not had much success. In this study, EM-E-11-4, a lathyrane-type diterpenoid extracted from Euphorbia...

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Detalles Bibliográficos
Autores principales: Liu, Qian, Cai, Pei, Guo, Siwei, Shi, Jiangong, Sun, Hua
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066893/
https://www.ncbi.nlm.nih.gov/pubmed/32108588
http://dx.doi.org/10.18632/aging.102842

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066893/
https://www.ncbi.nlm.nih.gov/pubmed/32108588
http://dx.doi.org/10.18632/aging.102842

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