Transcriptomic and metabolomic profiling of long-lived growth hormone releasing hormone knock-out mice: evidence for altered mitochondrial function and amino acid metabolism

Numerous genetic manipulations that extend lifespan in mice have been discovered over the past two decades, the most robust of which has arguably been the down regulation of growth hormone (GH) signaling. However, while decreased GH signaling has been associated with improved health and lifespan, ma...

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Detalles Bibliográficos
Autores principales: Hoffman, Jessica M., Poonawalla, Aliza, Icyuz, Mert, Swindell, William R., Wilson, Landon, Barnes, Stephen, Sun, Liou Y.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Impact Journals 2020
Materias:
Research Paper
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066919/
https://www.ncbi.nlm.nih.gov/pubmed/32091406
http://dx.doi.org/10.18632/aging.102822

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7066919/
https://www.ncbi.nlm.nih.gov/pubmed/32091406
http://dx.doi.org/10.18632/aging.102822

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