Optical control of the nuclear bile acid receptor FXR with a photohormone

Herein, we report a photoswitchable modulator for a nuclear hormone receptor that exerts its hormonal effects in a light-dependent fashion. The azobenzene AzoGW enables optical control of the farnesoid X receptor (FXR), a key regulator of hepatic bile acid, lipid and glucose metabolism. AzoGW was de...

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Detalles Bibliográficos
Autores principales: Morstein, Johannes, Trads, Julie B., Hinnah, Konstantin, Willems, Sabine, Barber, David M., Trauner, Michael, Merk, Daniel, Trauner, Dirk
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067245/
https://www.ncbi.nlm.nih.gov/pubmed/32190263
http://dx.doi.org/10.1039/c9sc02911g

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067245/
https://www.ncbi.nlm.nih.gov/pubmed/32190263
http://dx.doi.org/10.1039/c9sc02911g

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