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Optical control of the nuclear bile acid receptor FXR with a photohormone

Herein, we report a photoswitchable modulator for a nuclear hormone receptor that exerts its hormonal effects in a light-dependent fashion. The azobenzene AzoGW enables optical control of the farnesoid X receptor (FXR), a key regulator of hepatic bile acid, lipid and glucose metabolism. AzoGW was de...

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Detalles Bibliográficos
Autores principales:	Morstein, Johannes, Trads, Julie B., Hinnah, Konstantin, Willems, Sabine, Barber, David M., Trauner, Michael, Merk, Daniel, Trauner, Dirk
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Royal Society of Chemistry 2019
Materias:	Chemistry
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067245/ https://www.ncbi.nlm.nih.gov/pubmed/32190263 http://dx.doi.org/10.1039/c9sc02911g

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