IODVA1, a guanidinobenzimidazole derivative, targets Rac activity and Ras-driven cancer models

We report the synthesis and preliminary characterization of IODVA1, a potent small molecule that is active in xenograft mouse models of Ras-driven lung and breast cancers. In an effort to inhibit oncogenic Ras signaling, we combined in silico screening with inhibition of proliferation and colony for...

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Detalles Bibliográficos
Autores principales: Gasilina, Anjelika, Premnauth, Gurdat, Gurjar, Purujit, Biesiada, Jacek, Hegde, Shailaja, Milewski, David, Ma, Gang, Kalin, Tanya V., Merino, Edward, Meller, Jarek, Seibel, William, Cancelas, José A., Vinnedge, Lisa Privette, Nassar, Nicolas N.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Public Library of Science 2020
Materias:
Research Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067412/
https://www.ncbi.nlm.nih.gov/pubmed/32163428
http://dx.doi.org/10.1371/journal.pone.0229801

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067412/
https://www.ncbi.nlm.nih.gov/pubmed/32163428
http://dx.doi.org/10.1371/journal.pone.0229801

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