Ablation of IL-17A leads to severe colitis in IL-10-deficient mice: implications of myeloid-derived suppressor cells and NO production

IL-10 is an immune regulatory cytokine and its genetic defect leads to gastrointestinal inflammation in humans and mice. Moreover, the IL-23/T(h)17 axis is known to be involved in these inflammatory disorders. IL-17A, a representative cytokine produced by T(h)17 cells, has an important role for the...

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Detalles Bibliográficos
Autores principales: Tachibana, Masashi, Watanabe, Nobumasa, Koda, Yuzo, Oya, Yukako, Kaminuma, Osamu, Katayama, Kazufumi, Fan, Zifei, Sakurai, Fuminori, Kawabata, Kenji, Hiroi, Takachika, Mizuguchi, Hiroyuki
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Oxford University Press 2019
Materias:
Original Research
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067553/
https://www.ncbi.nlm.nih.gov/pubmed/31755523
http://dx.doi.org/10.1093/intimm/dxz076

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067553/
https://www.ncbi.nlm.nih.gov/pubmed/31755523
http://dx.doi.org/10.1093/intimm/dxz076

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