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Prediction of Clearance in Children from Adults Following Drug–Drug Interaction Studies: Application of Age-Dependent Exponent Model
BACKGROUND AND OBJECTIVE: Pharmacokinetic drug–drug interaction (DDI) studies are conducted in adult subjects during drug development but there are limited studies that have characterized pharmacokinetic DDI studies in children. The objective of this study was to evaluate if the DDI clearance values...
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
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Springer International Publishing
2020
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| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067713/ https://www.ncbi.nlm.nih.gov/pubmed/32056156 http://dx.doi.org/10.1007/s40268-020-00295-3 |