Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis

Histones are typically located within the intracellular compartment, and more specifically, within the nucleus. When histones are located within the extracellular compartment, they change roles and become damage-associated molecular patterns (DAMPs), promoting inflammation and coagulation. Patients...

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Detalles Bibliográficos
Autores principales: Frydman, Galit H., Tessier, Shannon N., Wong, Keith H. K., Vanderburg, Charles R., Fox, James G., Toner, Mehmet, Tompkins, Ronald G., Irimia, Daniel
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067782/
https://www.ncbi.nlm.nih.gov/pubmed/32165642
http://dx.doi.org/10.1038/s41598-020-61309-3

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067782/
https://www.ncbi.nlm.nih.gov/pubmed/32165642
http://dx.doi.org/10.1038/s41598-020-61309-3

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