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Megakaryocytes contain extranuclear histones and may be a source of platelet-associated histones during sepsis
Histones are typically located within the intracellular compartment, and more specifically, within the nucleus. When histones are located within the extracellular compartment, they change roles and become damage-associated molecular patterns (DAMPs), promoting inflammation and coagulation. Patients...
| Autores principales: | , , , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067782/ https://www.ncbi.nlm.nih.gov/pubmed/32165642 http://dx.doi.org/10.1038/s41598-020-61309-3 |