FAM111A protects replication forks from protein obstacles via its trypsin-like domain

Persistent protein obstacles on genomic DNA, such as DNA-protein crosslinks (DPCs) and tight nucleoprotein complexes, can block replication forks. DPCs can be removed by the proteolytic activities of the metalloprotease SPRTN or the proteasome in a replication-coupled manner; however, additional pro...

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Detalles Bibliográficos
Autores principales: Kojima, Yusuke, Machida, Yuka, Palani, Sowmiya, Caulfield, Thomas R., Radisky, Evette S., Kaufmann, Scott H., Machida, Yuichi J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067828/
https://www.ncbi.nlm.nih.gov/pubmed/32165630
http://dx.doi.org/10.1038/s41467-020-15170-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067828/
https://www.ncbi.nlm.nih.gov/pubmed/32165630
http://dx.doi.org/10.1038/s41467-020-15170-7

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