Formation of pre-pore complexes of pneumolysin is accompanied by a decrease in short-range order of lipid molecules throughout vesicle bilayers

Oligomers of pneumolysin form transmembrane channels in cholesterol-containing lipid bilayers. The mechanism of pore formation involves a multistage process in which the protein, at first, assembles into a ring-shaped complex on the outer-bilayer leaflet. In a subsequent step, the complex inserts in...

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Detalles Bibliográficos
Autores principales: Faraj, Bayan H. A., Collard, Liam, Cliffe, Rachel, Blount, Leanne A., Lonnen, Rana, Wallis, Russell, Andrew, Peter W., Hudson, Andrew J.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067851/
https://www.ncbi.nlm.nih.gov/pubmed/32165654
http://dx.doi.org/10.1038/s41598-020-60348-0

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7067851/
https://www.ncbi.nlm.nih.gov/pubmed/32165654
http://dx.doi.org/10.1038/s41598-020-60348-0

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