Cargando…

Patient-Specific Retinal Organoids Recapitulate Disease Features of Late-Onset Retinitis Pigmentosa

Although an increasing number of disease genes have been identified, the exact cellular mechanisms of retinitis pigmentosa (RP) remain largely unclear. Retinal organoids (ROs) derived from the induced pluripotent stem cells (iPSCs) of patients provide a potential but unvalidated platform for deciphe...

Descripción completa

Detalles Bibliográficos
Autores principales:	Gao, Mei-Ling, Lei, Xin-Lan, Han, Fang, He, Kai-Wen, Jin, Si-Qian, Zhang, You-You, Jin, Zi-Bing
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Frontiers Media S.A. 2020
Materias:	Cell and Developmental Biology
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068133/ https://www.ncbi.nlm.nih.gov/pubmed/32211407 http://dx.doi.org/10.3389/fcell.2020.00128

Ejemplares similares

Variant Profiling of a Large Cohort of 138 Chinese Families With Autosomal Dominant Retinitis Pigmentosa
por: Xiao, Ting, et al.
Publicado: (2021)

Modeling retinitis pigmentosa through patient-derived retinal organoids
por: Li, Yan-Ping, et al.
Publicado: (2021)

Stem cells set their sights on retinitis pigmentosa
por: Bennicelli, Jeannette L, et al.
Publicado: (2013)

Pre-mRNA Processing Factors and Retinitis Pigmentosa: RNA Splicing and Beyond
por: Yang, Chunbo, et al.
Publicado: (2021)

Mouse Retinal Organoid Growth and Maintenance in Longer-Term Culture
por: Völkner, Manuela, et al.
Publicado: (2021)

The Impact of Particulate Matter (PM2.5) on Human Retinal Development in hESC-Derived Retinal Organoids
por: Zeng, Yuxiao, et al.
Publicado: (2021)

Cost-effective sequence analysis of 113 genes in 1,192 probands with retinitis pigmentosa and Leber congenital amaurosis
por: Panneman, Daan M., et al.
Publicado: (2023)

Novel compound heterozygous variants in the USH2A gene associated with autosomal recessive retinitis pigmentosa without hearing loss
por: Huang, Yanxia, et al.
Publicado: (2023)

Long-term culture of patient-derived cardiac organoids recapitulated Duchenne muscular dystrophy cardiomyopathy and disease progression
por: Marini, Vittoria, et al.
Publicado: (2022)

Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients
por: Deng, Wen-Li, et al.
Publicado: (2018)

Gene Correction Reverses Ciliopathy and Photoreceptor Loss in iPSC-Derived Retinal Organoids from Retinitis Pigmentosa Patients
por: Deng, Wen-Li, et al.
Publicado: (2018)

Generation and Staging of Human Retinal Organoids Based on Self-Formed Ectodermal Autonomous Multi-Zone System
por: Li, Jinyan, et al.
Publicado: (2021)

Single Cell Transcriptomic Analyses Reveal the Impact of bHLH Factors on Human Retinal Organoid Development
por: Zhang, Xiangmei, et al.
Publicado: (2021)

Patient-specific iPSC-derived photoreceptor precursor cells as a means to investigate retinitis pigmentosa
por: Tucker, Budd A, et al.
Publicado: (2013)

Large-scale phenotypic drug screen identifies neuroprotectants in zebrafish and mouse models of retinitis pigmentosa
por: Zhang, Liyun, et al.
Publicado: (2021)

Genetic and Epigenetic Regulation of Brain Organoids
por: Wang, You-Wei, et al.
Publicado: (2022)

Genotype Profile of Global EYS-Associated Inherited Retinal Dystrophy and Clinical Findings in a Large Chinese Cohort
por: Xu, Ke, et al.
Publicado: (2021)

Expression Profiling Analysis Reveals Key MicroRNA–mRNA Interactions in Early Retinal Degeneration in Retinitis Pigmentosa
por: Anasagasti, Ander, et al.
Publicado: (2018)

Acute and Protracted Cell Death in Light-Induced Retinal Degeneration in the Canine Model of Rhodopsin Autosomal Dominant Retinitis Pigmentosa
por: Sudharsan, Raghavi, et al.
Publicado: (2017)

Versatile Genome Engineering Techniques Advance Human Ocular Disease Researches in Zebrafish
por: Zheng, Si-Si, et al.
Publicado: (2018)

Potential of Small Molecule–Mediated Reprogramming of Rod Photoreceptors to Treat Retinitis Pigmentosa
por: Nakamura, Paul A., et al.
Publicado: (2016)

Retinal Stem/Progenitor Cells Derived From Adult Müller Glia for the Treatment of Retinal Degeneration
por: Too, Lay Khoon, et al.
Publicado: (2021)

Epigenetic mechanisms of Müller glial reprogramming mediating retinal regeneration
por: Si, Tian-En, et al.
Publicado: (2023)

Brain organoids: Establishment and application
por: Chen, Hao, et al.
Publicado: (2022)

Human Amniotic Epithelial Stem Cell-Derived Retinal Pigment Epithelium Cells Repair Retinal Degeneration
por: Li, Jinying, et al.
Publicado: (2021)

Setting Eyes on the Retinal Pigment Epithelium
por: Moreno-Marmol, Tania, et al.
Publicado: (2018)

On the Generation and Regeneration of Retinal Ganglion Cells
por: Oliveira-Valença, Viviane M., et al.
Publicado: (2020)

Emerging Role of Exosomes in Retinal Diseases
por: Zhang, Zhengyu, et al.
Publicado: (2021)

Retinal degeneration in rpgra mutant zebrafish
por: Liu, Xiliang, et al.
Publicado: (2023)

Vitronectin-based hydrogels recapitulate neuroblastoma growth conditions
por: Monferrer, Ezequiel, et al.
Publicado: (2022)

Identification of Four Novel Variants and Determination of Genotype–Phenotype Correlations for ABCA4 Variants Associated With Inherited Retinal Degenerations
por: Zhu, Qing, et al.
Publicado: (2021)

Shaping the Microglia in Retinal Degenerative Diseases Using Stem Cell Therapy: Practice and Prospects
por: Jin, Ni, et al.
Publicado: (2021)

Retinal fluid is associated with cytokines of aqueous humor in age-related macular degeneration using automatic 3-dimensional quantification
por: Song, Siyuan, et al.
Publicado: (2023)

Retinal organoids and microfluidic chip-based approaches to explore the retinitis pigmentosa with USH2A mutations
por: Su, Ting, et al.
Publicado: (2022)

An Integrative and Modular Framework to Recapitulate Emergent Behavior in Cell Migration
por: Cuenca, Marina B., et al.
Publicado: (2020)

Retinal Degeneration in MPS-IIIA Mouse Model
por: Intartaglia, Daniela, et al.
Publicado: (2020)

Different Phenotypes in Pseudodominant Inherited Retinal Dystrophies
por: Habibi, Imen, et al.
Publicado: (2021)

Regulations of Retinal Inflammation: Focusing on Müller Glia
por: Chen, Yingying, et al.
Publicado: (2022)

Updating the Genetic Landscape of Inherited Retinal Dystrophies
por: García Bohórquez, Belén, et al.
Publicado: (2021)

Extracellular vesicles: an emerging player in retinal homeostasis
por: Chatterjee, Amit, et al.
Publicado: (2023)

Cannot write session to /tmp/vufind_sessions/sess_n93hctnoqmf5ean6d59nqo70lr