CRISPR/Cas9-mediated knockout of MLL5 enhances apoptotic effect of cisplatin in HeLa cells in vitro

Mixed lineage leukemia 5 (MLL5) transactivates the expression of E6 and E7 oncogenes in cervical cancer cells. In this study, we utilized CRISPR/Cas9 system with the aim to target HPV-E6 and MLL5 to enhance apoptosis efficiency in HPV-18 positive HeLa cells and to improve chemotherapeutic efficacy o...

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Detalles Bibliográficos
Autores principales: Pirouzfar, Mohammad, Amiri, Farshid, Dianatpour, Mehdi, Takhshid, Mohammad Ali
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Leibniz Research Centre for Working Environment and Human Factors 2020
Materias:
Original Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068203/
https://www.ncbi.nlm.nih.gov/pubmed/32194363
http://dx.doi.org/10.17179/excli2019-1957

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068203/
https://www.ncbi.nlm.nih.gov/pubmed/32194363
http://dx.doi.org/10.17179/excli2019-1957

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