Cargando…

Construction of Glycometabolism- and Hormone-Related lncRNA-Mediated Feedforward Loop Networks Reveals Global Patterns of lncRNAs and Drug Repurposing in Gestational Diabetes

Gestational diabetes mellitus (GDM) is a condition associated with the onset of abnormal glucose tolerance during pregnancy. Long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and genes can form lncRNA-mediated feedforward loops (lnc-FFLs), which are functional network motifs that regulate a wide r...

Descripción completa

Detalles Bibliográficos
Autores principales: Fu, Xuelian, Cong, Huifang, Zhao, Shuyu, Li, Yan, Liu, Tianyi, Sun, Yuhong, Lv, Nan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Frontiers Media S.A. 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068675/
https://www.ncbi.nlm.nih.gov/pubmed/32210913
http://dx.doi.org/10.3389/fendo.2020.00093
_version_ 1783505631633735680
author Fu, Xuelian
Cong, Huifang
Zhao, Shuyu
Li, Yan
Liu, Tianyi
Sun, Yuhong
Lv, Nan
author_facet Fu, Xuelian
Cong, Huifang
Zhao, Shuyu
Li, Yan
Liu, Tianyi
Sun, Yuhong
Lv, Nan
author_sort Fu, Xuelian
collection PubMed
description Gestational diabetes mellitus (GDM) is a condition associated with the onset of abnormal glucose tolerance during pregnancy. Long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and genes can form lncRNA-mediated feedforward loops (lnc-FFLs), which are functional network motifs that regulate a wide range of biological processes and diseases. However, lnc-FFL network motifs have not been systematically investigated in GDM, and their role in the disease remains largely unknown. In the present study, a global lnc-FFL network was constructed and analyzed. Glycometabolism- and hormone-related lnc-FFL networks were extracted from the global network. An integrated algorithm was designed to identify dysregulated glycometabolism- and hormone-related lnc-FFLs in GDM. The patterns of dysregulated lnc-FFLs in GDM were complex. Moreover, there were strong associations between dysregulated glycometabolism- and hormone-related lnc-FFLs in GDM. Core modules were extracted from the dysregulated lnc-FFL networks in GDM and showed specific and essential functions. In addition, dysregulated lnc-FFLs could combine with ceRNAs and form more complex modules, which could play novel roles in GDM. Notably, we discovered that the dysregulated lnc-FFLs were enriched in the thyroid hormone signaling pathway. Some drug-repurposing candidates, such as hormonal drugs, could be identified based on lnc-FFLs in GDM. In summary, the present study highlighted the effect of dysregulated glycometabolism- and hormone-related lnc-FFLs in GDM and revealed their potential for the discovery of novel biomarkers and therapeutic targets for GDM.
format Online
Article
Text
id pubmed-7068675
institution National Center for Biotechnology Information
language English
publishDate 2020
publisher Frontiers Media S.A.
record_format MEDLINE/PubMed
spelling pubmed-70686752020-03-24 Construction of Glycometabolism- and Hormone-Related lncRNA-Mediated Feedforward Loop Networks Reveals Global Patterns of lncRNAs and Drug Repurposing in Gestational Diabetes Fu, Xuelian Cong, Huifang Zhao, Shuyu Li, Yan Liu, Tianyi Sun, Yuhong Lv, Nan Front Endocrinol (Lausanne) Endocrinology Gestational diabetes mellitus (GDM) is a condition associated with the onset of abnormal glucose tolerance during pregnancy. Long non-coding RNAs (lncRNAs), microRNAs (miRNAs), and genes can form lncRNA-mediated feedforward loops (lnc-FFLs), which are functional network motifs that regulate a wide range of biological processes and diseases. However, lnc-FFL network motifs have not been systematically investigated in GDM, and their role in the disease remains largely unknown. In the present study, a global lnc-FFL network was constructed and analyzed. Glycometabolism- and hormone-related lnc-FFL networks were extracted from the global network. An integrated algorithm was designed to identify dysregulated glycometabolism- and hormone-related lnc-FFLs in GDM. The patterns of dysregulated lnc-FFLs in GDM were complex. Moreover, there were strong associations between dysregulated glycometabolism- and hormone-related lnc-FFLs in GDM. Core modules were extracted from the dysregulated lnc-FFL networks in GDM and showed specific and essential functions. In addition, dysregulated lnc-FFLs could combine with ceRNAs and form more complex modules, which could play novel roles in GDM. Notably, we discovered that the dysregulated lnc-FFLs were enriched in the thyroid hormone signaling pathway. Some drug-repurposing candidates, such as hormonal drugs, could be identified based on lnc-FFLs in GDM. In summary, the present study highlighted the effect of dysregulated glycometabolism- and hormone-related lnc-FFLs in GDM and revealed their potential for the discovery of novel biomarkers and therapeutic targets for GDM. Frontiers Media S.A. 2020-03-06 /pmc/articles/PMC7068675/ /pubmed/32210913 http://dx.doi.org/10.3389/fendo.2020.00093 Text en Copyright © 2020 Fu, Cong, Zhao, Li, Liu, Sun and Lv. http://creativecommons.org/licenses/by/4.0/ This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
spellingShingle Endocrinology
Fu, Xuelian
Cong, Huifang
Zhao, Shuyu
Li, Yan
Liu, Tianyi
Sun, Yuhong
Lv, Nan
Construction of Glycometabolism- and Hormone-Related lncRNA-Mediated Feedforward Loop Networks Reveals Global Patterns of lncRNAs and Drug Repurposing in Gestational Diabetes
title Construction of Glycometabolism- and Hormone-Related lncRNA-Mediated Feedforward Loop Networks Reveals Global Patterns of lncRNAs and Drug Repurposing in Gestational Diabetes
title_full Construction of Glycometabolism- and Hormone-Related lncRNA-Mediated Feedforward Loop Networks Reveals Global Patterns of lncRNAs and Drug Repurposing in Gestational Diabetes
title_fullStr Construction of Glycometabolism- and Hormone-Related lncRNA-Mediated Feedforward Loop Networks Reveals Global Patterns of lncRNAs and Drug Repurposing in Gestational Diabetes
title_full_unstemmed Construction of Glycometabolism- and Hormone-Related lncRNA-Mediated Feedforward Loop Networks Reveals Global Patterns of lncRNAs and Drug Repurposing in Gestational Diabetes
title_short Construction of Glycometabolism- and Hormone-Related lncRNA-Mediated Feedforward Loop Networks Reveals Global Patterns of lncRNAs and Drug Repurposing in Gestational Diabetes
title_sort construction of glycometabolism- and hormone-related lncrna-mediated feedforward loop networks reveals global patterns of lncrnas and drug repurposing in gestational diabetes
topic Endocrinology
url https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7068675/
https://www.ncbi.nlm.nih.gov/pubmed/32210913
http://dx.doi.org/10.3389/fendo.2020.00093
work_keys_str_mv AT fuxuelian constructionofglycometabolismandhormonerelatedlncrnamediatedfeedforwardloopnetworksrevealsglobalpatternsoflncrnasanddrugrepurposingingestationaldiabetes
AT conghuifang constructionofglycometabolismandhormonerelatedlncrnamediatedfeedforwardloopnetworksrevealsglobalpatternsoflncrnasanddrugrepurposingingestationaldiabetes
AT zhaoshuyu constructionofglycometabolismandhormonerelatedlncrnamediatedfeedforwardloopnetworksrevealsglobalpatternsoflncrnasanddrugrepurposingingestationaldiabetes
AT liyan constructionofglycometabolismandhormonerelatedlncrnamediatedfeedforwardloopnetworksrevealsglobalpatternsoflncrnasanddrugrepurposingingestationaldiabetes
AT liutianyi constructionofglycometabolismandhormonerelatedlncrnamediatedfeedforwardloopnetworksrevealsglobalpatternsoflncrnasanddrugrepurposingingestationaldiabetes
AT sunyuhong constructionofglycometabolismandhormonerelatedlncrnamediatedfeedforwardloopnetworksrevealsglobalpatternsoflncrnasanddrugrepurposingingestationaldiabetes
AT lvnan constructionofglycometabolismandhormonerelatedlncrnamediatedfeedforwardloopnetworksrevealsglobalpatternsoflncrnasanddrugrepurposingingestationaldiabetes