Cargando…
A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum
BACKGROUND: DLG2, also known as postsynaptic density protein-93 (PSD-93) or chapsyn-110, is an excitatory postsynaptic scaffolding protein that interacts with synaptic surface receptors and signaling molecules. A recent study has demonstrated that mutations in the DLG2 promoter region are significan...
Autores principales: | Yoo, Taesun, Kim, Sun-Gyun, Yang, Soo Hyun, Kim, Hyun, Kim, Eunjoon, Kim, Soo Young |
---|---|
Formato: | Online Artículo Texto |
Lenguaje: | English |
Publicado: |
BioMed Central
2020
|
Materias: | |
Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069029/ https://www.ncbi.nlm.nih.gov/pubmed/32164788 http://dx.doi.org/10.1186/s13229-020-00324-7 |
Ejemplares similares
-
A Deficiency of the Psychiatric Risk Gene DLG2/PSD-93 Causes Excitatory Synaptic Deficits in the Dorsolateral Striatum
por: Yoo, Taesun, et al.
Publicado: (2022) -
Shank3 Exons 14–16 Deletion in Glutamatergic Neurons Leads to Social and Repetitive Behavioral Deficits Associated With Increased Cortical Layer 2/3 Neuronal Excitability
por: Yoo, Taesun, et al.
Publicado: (2019) -
GABA Neuronal Deletion of Shank3 Exons 14–16 in Mice Suppresses Striatal Excitatory Synaptic Input and Induces Social and Locomotor Abnormalities
por: Yoo, Taesun, et al.
Publicado: (2018) -
Phospho-regulated Drosophila adducin is a determinant of synaptic plasticity in a complex with Dlg and PIP(2) at the larval neuromuscular junction
por: Wang, Simon Ji Hau, et al.
Publicado: (2014) -
A TBR1-K228E Mutation Induces Tbr1 Upregulation, Altered Cortical Distribution of Interneurons, Increased Inhibitory Synaptic Transmission, and Autistic-Like Behavioral Deficits in Mice
por: Yook, Chaehyun, et al.
Publicado: (2019)