Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase

Simplified analogues of the potent human amylase inhibitor montbretin A were synthesised and shown to bind tightly, K(I) = 60 and 70 nM, with improved specificity over medically relevant glycosidases, making them promising candidates for controlling blood glucose. Crystallographic analysis confirmed...

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Detalles Bibliográficos
Autores principales: Tysoe, Christina R., Caner, Sami, Calvert, Matthew B., Win-Mason, Anna, Brayer, Gary D., Withers, Stephen G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Royal Society of Chemistry 2019
Materias:
Chemistry
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069248/
https://www.ncbi.nlm.nih.gov/pubmed/32206255
http://dx.doi.org/10.1039/c9sc02610j

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069248/
https://www.ncbi.nlm.nih.gov/pubmed/32206255
http://dx.doi.org/10.1039/c9sc02610j

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