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Synthesis of montbretin A analogues yields potent competitive inhibitors of human pancreatic α-amylase
Simplified analogues of the potent human amylase inhibitor montbretin A were synthesised and shown to bind tightly, K(I) = 60 and 70 nM, with improved specificity over medically relevant glycosidases, making them promising candidates for controlling blood glucose. Crystallographic analysis confirmed...
| Autores principales: | , , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Royal Society of Chemistry
2019
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069248/ https://www.ncbi.nlm.nih.gov/pubmed/32206255 http://dx.doi.org/10.1039/c9sc02610j |