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The mechanism of Hsp90-induced oligomerizaton of Tau

Aggregation of the microtubule-associated protein Tau is a hallmark of Alzheimer’s disease with Tau oligomers suspected as the most toxic agent. Tau is a client of the molecular chaperone Hsp90, although it is unclear whether and how the chaperone massages the structure of intrinsically disordered T...

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Detalles Bibliográficos
Autores principales: Weickert, S., Wawrzyniuk, M., John, L. H., Rüdiger, S. G. D., Drescher, M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: American Association for the Advancement of Science 2020
Materias:
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069708/
https://www.ncbi.nlm.nih.gov/pubmed/32201713
http://dx.doi.org/10.1126/sciadv.aax6999