Comprehensive fitness maps of Hsp90 show widespread environmental dependence

Gene-environment interactions have long been theorized to influence molecular evolution. However, the environmental dependence of most mutations remains unknown. Using deep mutational scanning, we engineered yeast with all 44,604 single codon changes encoding 14,160 amino acid variants in Hsp90 and...

Descripción completa

Detalles Bibliográficos
Autores principales: Flynn, Julia M, Rossouw, Ammeret, Cote-Hammarlof, Pamela, Fragata, Inês, Mavor, David, Hollins, Carl, Bank, Claudia, Bolon, Daniel NA
Formato: Online Artículo Texto
Lenguaje:English
Publicado: eLife Sciences Publications, Ltd 2020
Materias:
Evolutionary Biology
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069724/
https://www.ncbi.nlm.nih.gov/pubmed/32129763
http://dx.doi.org/10.7554/eLife.53810

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069724/
https://www.ncbi.nlm.nih.gov/pubmed/32129763
http://dx.doi.org/10.7554/eLife.53810

Ejemplares similares