Amino acid levels determine metabolism and CYP450 function of hepatocytes and hepatoma cell lines

Predicting drug-induced liver injury in a preclinical setting remains challenging, as cultured primary human hepatocytes (PHHs), pluripotent stem cell-derived hepatocyte-like cells (HLCs), and hepatoma cells exhibit poor drug biotransformation capacity. We here demonstrate that hepatic functionality...

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Detalles Bibliográficos
Autores principales: Boon, Ruben, Kumar, Manoj, Tricot, Tine, Elia, Ilaria, Ordovas, Laura, Jacobs, Frank, One, Jennifer, De Smedt, Jonathan, Eelen, Guy, Bird, Matthew, Roelandt, Philip, Doglioni, Ginevra, Vriens, Kim, Rossi, Matteo, Vazquez, Marta Aguirre, Vanwelden, Thomas, Chesnais, François, El Taghdouini, Adil, Najimi, Mustapha, Sokal, Etienne, Cassiman, David, Snoeys, Jan, Monshouwer, Mario, Hu, Wei-Shou, Lange, Christian, Carmeliet, Peter, Fendt, Sarah-Maria, Verfaillie, Catherine M.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069944/
https://www.ncbi.nlm.nih.gov/pubmed/32170132
http://dx.doi.org/10.1038/s41467-020-15058-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069944/
https://www.ncbi.nlm.nih.gov/pubmed/32170132
http://dx.doi.org/10.1038/s41467-020-15058-6

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