Organoid cultures of MELAS neural cells reveal hyperactive Notch signaling that impacts neurodevelopment

Mutations in mitochondrial DNA (mtDNA), typically maternally inherited, can result in severe neurological conditions. There is currently no cure for mitochondrial DNA diseases and treatments focus on management of the symptoms rather than correcting the defects downstream of the mtDNA mutation. Mito...

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Detalles Bibliográficos
Autores principales: Winanto, Khong, Zi Jian, Soh, Boon-Seng, Fan, Yong, Ng, Shi-Yan
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069952/
https://www.ncbi.nlm.nih.gov/pubmed/32170107
http://dx.doi.org/10.1038/s41419-020-2383-6

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069952/
https://www.ncbi.nlm.nih.gov/pubmed/32170107
http://dx.doi.org/10.1038/s41419-020-2383-6

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