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Organoid cultures of MELAS neural cells reveal hyperactive Notch signaling that impacts neurodevelopment
Mutations in mitochondrial DNA (mtDNA), typically maternally inherited, can result in severe neurological conditions. There is currently no cure for mitochondrial DNA diseases and treatments focus on management of the symptoms rather than correcting the defects downstream of the mtDNA mutation. Mito...
| Autores principales: | , , , , |
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| Formato: | Online Artículo Texto |
| Lenguaje: | English |
| Publicado: |
Nature Publishing Group UK
2020
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| Materias: | |
| Acceso en línea: | https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069952/ https://www.ncbi.nlm.nih.gov/pubmed/32170107 http://dx.doi.org/10.1038/s41419-020-2383-6 |