Single molecule analysis reveals monomeric XPA bends DNA and undergoes episodic linear diffusion during damage search

Nucleotide excision repair (NER) removes a wide range of DNA lesions, including UV-induced photoproducts and bulky base adducts. XPA is an essential protein in eukaryotic NER, although reports about its stoichiometry and role in damage recognition are controversial. Here, by PeakForce Tapping atomic...

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Detalles Bibliográficos
Autores principales: Beckwitt, Emily C., Jang, Sunbok, Carnaval Detweiler, Isadora, Kuper, Jochen, Sauer, Florian, Simon, Nina, Bretzler, Johanna, Watkins, Simon C., Carell, Thomas, Kisker, Caroline, Van Houten, Bennett
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069974/
https://www.ncbi.nlm.nih.gov/pubmed/32170071
http://dx.doi.org/10.1038/s41467-020-15168-1

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069974/
https://www.ncbi.nlm.nih.gov/pubmed/32170071
http://dx.doi.org/10.1038/s41467-020-15168-1

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