Cargando…

Microglia clear neuron-released α-synuclein via selective autophagy and prevent neurodegeneration

Microglia maintain brain homeostasis by removing neuron-derived components such as myelin and cell debris. The evidence linking microglia to neurodegenerative diseases is growing; however, the precise mechanisms remain poorly understood. Herein, we report a neuroprotective role for microglia in the...

Descripción completa

Detalles Bibliográficos
Autores principales:	Choi, Insup, Zhang, Yuanxi, Seegobin, Steven P., Pruvost, Mathilde, Wang, Qian, Purtell, Kerry, Zhang, Bin, Yue, Zhenyu
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	Nature Publishing Group UK 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7069981/ https://www.ncbi.nlm.nih.gov/pubmed/32170061 http://dx.doi.org/10.1038/s41467-020-15119-w

Ejemplares similares

Regulation of α-synuclein homeostasis and inflammasome activation by microglial autophagy
por: Choi, Insup, et al.
Publicado: (2022)

Disruption of Neuronal Autophagy by Infected Microglia Results in Neurodegeneration
por: Alirezaei, Mehrdad, et al.
Publicado: (2008)

β1-integrin-dependent migration of microglia in response to neuron-released α-synuclein
por: Kim, Changyoun, et al.
Publicado: (2014)

Neurodegeneration and the ordered assembly of α-synuclein
por: Spillantini, Maria Grazia, et al.
Publicado: (2017)

Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity
por: Bido, Simone, et al.
Publicado: (2021)

α-Synuclein Immunotherapy Blocks Uptake and Templated Propagation of Misfolded α-Synuclein and Neurodegeneration
por: Tran, Hien T., et al.
Publicado: (2014)

α‐synuclein suppresses microglial autophagy and promotes neurodegeneration in a mouse model of Parkinson’s disease
por: Tu, Hai‐Yue, et al.
Publicado: (2021)

Autophagy and Microglia: Novel Partners in Neurodegeneration and Aging
por: Plaza-Zabala, Ainhoa, et al.
Publicado: (2017)

The Interplay between α-Synuclein and Microglia in α-Synucleinopathies
por: Deyell, Jacob S., et al.
Publicado: (2023)

Author Correction: Microglia-specific overexpression of α-synuclein leads to severe dopaminergic neurodegeneration by phagocytic exhaustion and oxidative toxicity
por: Bido, Simone, et al.
Publicado: (2021)

Targeted proteolytic products of τ and α-synuclein in neurodegeneration
por: Xia, Yuxing, et al.
Publicado: (2021)

Modelling α-Synuclein Aggregation and Neurodegeneration with Fibril Seeds in Primary Cultures of Mouse Dopaminergic Neurons
por: Tourville, Aurore, et al.
Publicado: (2022)

A Critical Role of Autophagy in Regulating Microglia Polarization in Neurodegeneration
por: Jin, Meng-meng, et al.
Publicado: (2018)

Rifampicin quinone pretreatment improves neuronal survival by modulating microglia inflammation induced by α-synuclein
por: Acuña, Leonardo, et al.
Publicado: (2020)

Effect of chemokine CC ligand 2 (CCL2) on α-synuclein-induced microglia proliferation and neuronal apoptosis
por: Zhang, Lijun, et al.
Publicado: (2018)

Small molecules to prevent the neurodegeneration caused by α-synuclein aggregation
por: Peña-Díaz, Samuel, et al.
Publicado: (2020)

Iron Deposition Leads to Neuronal α-Synuclein Pathology by Inducing Autophagy Dysfunction
por: Wan, Wenbin, et al.
Publicado: (2017)

Posttranslational Modifications and Clearing of α-Synuclein Aggregates in Yeast
por: Popova, Blagovesta, et al.
Publicado: (2015)

Glucocerebrosidase deficiency promotes release of α-synuclein fibrils from cultured neurons
por: Gegg, Matthew E, et al.
Publicado: (2020)

Post-translational modifications of α-synuclein contribute to neurodegeneration in the colon of elderly individuals
por: XUAN, QI, et al.
Publicado: (2016)

Primary Phagocytosis of Neurons by Inflamed Microglia: Potential Roles in Neurodegeneration
por: Neher, Jonas J., et al.
Publicado: (2012)

Evaluation of ABT-888 in the amelioration of α-synuclein fibril-induced neurodegeneration
por: Hastings, Lyndsay, et al.
Publicado: (2022)

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegeneration in Drosophila
por: Bridi, Jessika C, et al.
Publicado: (2021)

Alpha Synuclein: Neurodegeneration and Inflammation
por: Forloni, Gianluigi
Publicado: (2023)

Phosphorylation of Tau and α-Synuclein Induced Neurodegeneration in MPTP Mouse Model of Parkinson’s Disease
por: Hu, Shanshan, et al.
Publicado: (2020)

Neuroimmunological processes in Parkinson's disease and their relation to α-synuclein: microglia as the referee between neuronal processes and peripheral immunity
por: Sanchez-Guajardo, Vanesa, et al.
Publicado: (2013)

Pink1 interacts with α-synuclein and abrogates α-synuclein-induced neurotoxicity by activating autophagy
por: Liu, Jia, et al.
Publicado: (2017)

α-Synuclein leaves autophagy feeling compromised
por: Short, Ben
Publicado: (2010)

The release of toxic oligomers from α-synuclein fibrils induces dysfunction in neuronal cells
por: Cascella, Roberta, et al.
Publicado: (2021)

Lysosomal exocytosis releases pathogenic α-synuclein species from neurons in synucleinopathy models
por: Xie, Ying Xue, et al.
Publicado: (2022)

Assembly of α-synuclein and neurodegeneration in the central nervous system of heterozygous M83 mice following the peripheral administration of α-synuclein seeds
por: Macdonald, Jennifer A., et al.
Publicado: (2021)

Selective neurodegeneration generated by intravenous α‐synuclein pre‐formed fibril administration is not associated with endogenous α‐synuclein levels in the rat brain
por: Kuan, Wei‐Li, et al.
Publicado: (2022)

α-Synuclein and neuronal cell death
por: Cookson, Mark R
Publicado: (2009)

α-Synuclein and Neuronal Cell Death
por: Yasuda, Toru, et al.
Publicado: (2012)

Catecholamines and Neurodegeneration in Parkinson’s Disease—From Diagnostic Marker to Aggregations of α-Synuclein
por: Sawada, Hideyuki, et al.
Publicado: (2013)

Glucocerebrosidase Deficiency in Drosophila Results in α-Synuclein-Independent Protein Aggregation and Neurodegeneration
por: Davis, Marie Y., et al.
Publicado: (2016)

Lack of additive role of ageing in nigrostriatal neurodegeneration triggered by α-synuclein overexpression
por: Bourdenx, Mathieu, et al.
Publicado: (2015)

α-Synuclein and Polyunsaturated Fatty Acids: Molecular Basis of the Interaction and Implication in Neurodegeneration
por: Fecchio, Chiara, et al.
Publicado: (2018)

Lipids: Key Players That Modulate α-Synuclein Toxicity and Neurodegeneration in Parkinson’s Disease
por: Mori, Akio, et al.
Publicado: (2020)

α-Synuclein-mediated neurodegeneration in Dementia with Lewy bodies: the pathobiology of a paradox
por: Simon, Christopher, et al.
Publicado: (2021)

Cannot write session to /tmp/vufind_sessions/sess_8qock6vkckj8nfkr38jog9805r