An amber obligate active site-directed ligand evolution technique for phage display

Although noncanonical amino acids (ncAAs) were first incorporated into phage libraries through amber suppression nearly two decades ago, their application for use in drug discovery has been limited due to inherent library bias towards sense-containing phages. Here, we report a technique based on sup...

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Detalles Bibliográficos
Autores principales: Tharp, Jeffery M., Hampton, J. Trae, Reed, Catrina A., Ehnbom, Andreas, Chen, Peng-Hsun Chase, Morse, Jared S., Kurra, Yadagirri, Pérez, Lisa M., Xu, Shiqing, Liu, Wenshe Ray
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070036/
https://www.ncbi.nlm.nih.gov/pubmed/32170178
http://dx.doi.org/10.1038/s41467-020-15057-7

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070036/
https://www.ncbi.nlm.nih.gov/pubmed/32170178
http://dx.doi.org/10.1038/s41467-020-15057-7

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