Protection from β-cell apoptosis by inhibition of TGF-β/Smad3 signaling

Prevailing insulin resistance and the resultant hyperglycemia elicits a compensatory response from pancreatic islet beta cells (β-cells) that involves increases in β-cell function and β-cell mass. However, the sustained metabolic stress eventually leads to β-cell failure characterized by severe β-ce...

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Detalles Bibliográficos
Autores principales: Lee, Ji-Hyeon, Mellado-Gil, Jose Manuel, Bahn, Young Jae, Pathy, Sushrut M., Zhang, Ying E., Rane, Sushil G.
Formato: Online Artículo Texto
Lenguaje:English
Publicado: Nature Publishing Group UK 2020
Materias:
Article
Acceso en línea:https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070087/
https://www.ncbi.nlm.nih.gov/pubmed/32170115
http://dx.doi.org/10.1038/s41419-020-2365-8

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070087/
https://www.ncbi.nlm.nih.gov/pubmed/32170115
http://dx.doi.org/10.1038/s41419-020-2365-8

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