Cargando…

Effect of Copper on the Mitochondrial Carnitine/Acylcarnitine Carrier Via Interaction with Cys136 and Cys155. Possible Implications in Pathophysiology

The effect of copper on the mitochondrial carnitine/acylcarnitine carrier (CAC) was studied. Transport function was assayed as [(3)H]carnitine/carnitine antiport in proteoliposomes reconstituted with the native protein extracted from rat liver mitochondria or with the recombinant CAC over-expressed...

Descripción completa

Detalles Bibliográficos
Autores principales:	Giangregorio, Nicola, Tonazzi, Annamaria, Console, Lara, Prejanò, Mario, Marino, Tiziana, Russo, Nino, Indiveri, Cesare
Formato:	Online Artículo Texto
Lenguaje:	English
Publicado:	MDPI 2020
Materias:	Article
Acceso en línea:	https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7070283/ https://www.ncbi.nlm.nih.gov/pubmed/32070004 http://dx.doi.org/10.3390/molecules25040820

Ejemplares similares

Inhibition of the Mitochondrial Carnitine/Acylcarnitine Carrier by Itaconate through Irreversible Binding to Cysteine 136: Possible Pathophysiological Implications
por: Giangregorio, Nicola, et al.
Publicado: (2023)

The Mycotoxin Patulin Inhibits the Mitochondrial Carnitine/Acylcarnitine Carrier (SLC25A20) by Interaction with Cys136 Implications for Human Health
por: Giangregorio, Nicola, et al.
Publicado: (2023)

The Mitochondrial Carnitine Acyl-carnitine Carrier (SLC25A20): Molecular Mechanisms of Transport, Role in Redox Sensing and Interaction with Drugs
por: Tonazzi, Annamaria, et al.
Publicado: (2021)

Characterization of Exosomal SLC22A5 (OCTN2) carnitine transporter
por: Console, Lara, et al.
Publicado: (2018)

Molecular Mechanism of Inhibition of the Mitochondrial Carnitine/Acylcarnitine Transporter by Omeprazole Revealed by Proteoliposome Assay, Mutagenesis and Bioinformatics
por: Tonazzi, Annamaria, et al.
Publicado: (2013)

Carnitine Traffic in Cells. Link With Cancer
por: Console, Lara, et al.
Publicado: (2020)

Cys Site-Directed Mutagenesis of the Human SLC1A5 (ASCT2) Transporter: Structure/Function Relationships and Crucial Role of Cys467 for Redox Sensing and Glutamine Transport
por: Scalise, Mariafrancesca, et al.
Publicado: (2018)

The Link Between the Mitochondrial Fatty Acid Oxidation Derangement and Kidney Injury
por: Console, Lara, et al.
Publicado: (2020)

NMR Characterization of Long-Chain Fatty Acylcarnitine Binding to the Mitochondrial Carnitine/Acylcarnitine Carrier
por: Zhang, Ningning, et al.
Publicado: (2022)

Cys–Cys and Cys–Lys Stapling of Unprotected Peptides Enabled by Hypervalent Iodine Reagents
por: Ceballos, Javier, et al.
Publicado: (2021)

Proteoliposomes as Tool for Assaying Membrane Transporter Functions and Interactions with Xenobiotics
por: Scalise, Mariafrancesca, et al.
Publicado: (2013)

Partial catalytic Cys oxidation of human GAPDH to Cys-sulfonic acid.
por: Lia, Andrea, et al.
Publicado: (2020)

Galectin-13, a different prototype galectin, does not bind β-galacto-sides and forms dimers via intermolecular disulfide bridges between Cys-136 and Cys-138
por: Su, Jiyong, et al.
Publicado: (2018)

Overproduction, Purification, and Stability of the Functionally Active Human Carnitine Acetyl Transferase
por: Giudice, Deborah, et al.
Publicado: (2022)

The significance of acylcarnitine ratio indices in diagnosing carnitine-acylcarnitine translocase deficiency
por: Shi, Congcong, et al.
Publicado: (2023)

Acylcarnitine ratio indices in diagnosing carnitine-acylcarnitine translocase deficiency in newborns
por: Tan, Yifei, et al.
Publicado: (2023)

Roles of cysteines Cys115 and Cys201 in the assembly and thermostability of grouper betanodavirus particles
por: Wang, Chun-Hsiung, et al.
Publicado: (2010)

Expression of cysLT1 and cysLT2 Receptor in Chronic Hyperplastic Eosinophilic Sinusitis
por: Ouyang, Yuhui, et al.
Publicado: (2009)

Extirpation of a Tubo-Ovarian Cys
por: Archibald, R. A.
Publicado: (1893)

Assessment of Babesia bovis 6cys A and 6cys B as components of transmission blocking vaccines for babesiosis
por: Alzan, Heba F., et al.
Publicado: (2021)

Baicalin Ameliorates Radiation-Induced Lung Injury by Inhibiting the CysLTs/CysLT1 Signaling Pathway
por: Bao, Wu-An, et al.
Publicado: (2022)

Blood Pressure Levels in Male Carriers of Arg82Cys in CD300LG
por: Støy, Julie, et al.
Publicado: (2014)

N-glycosylation is crucial for trafficking and stability of SLC3A2 (CD98)
por: Console, Lara, et al.
Publicado: (2022)

Cholesterol stimulates the cellular uptake of L-carnitine by the carnitine/organic cation transporter novel 2 (OCTN2)
por: Zhang, Lu, et al.
Publicado: (2021)

L-Carnitine and Acylcarnitines: Mitochondrial Biomarkers for Precision Medicine
por: McCann, Marc R., et al.
Publicado: (2021)

Complex I within Oxidatively Stressed Bovine Heart Mitochondria Is Glutathionylated on Cys-531 and Cys-704 of the 75-kDa Subunit: POTENTIAL ROLE OF CYS RESIDUES IN DECREASING OXIDATIVE DAMAGE
por: Hurd, Thomas R., et al.
Publicado: (2008)

Redox properties of Cys(2)His(2) and Cys(4) zinc fingers determined by electrospray ionization mass spectrometry
por: Smirnova, Julia, et al.
Publicado: (2018)

Conversion of Methionine to Cysteine in Lactobacillus paracasei Depends on the Highly Mobile cysK-ctl-cysE Gene Cluster
por: Wüthrich, Daniel, et al.
Publicado: (2018)

Characterization of a Novel Mitochondrial Ascorbate Transporter From Rat Liver and Potato Mitochondria
por: Scalera, Vito, et al.
Publicado: (2018)

QM Cluster or QM/MM in Computational Enzymology: The Test Case of LigW-Decarboxylase
por: Prejanò, Mario, et al.
Publicado: (2018)

On the Inhibition Mechanism of Glutathione Transferase P1 by Piperlongumine. Insight From Theory
por: Prejanò, Mario, et al.
Publicado: (2018)

Mechanism of Allosteric Modulation of the Cys-loop Receptors
por: Chang, Yongchang, et al.
Publicado: (2010)

Principles of agonist recognition in Cys-loop receptors
por: Lynagh, Timothy, et al.
Publicado: (2014)

The desensitization gate of inhibitory Cys-loop receptors
por: Gielen, Marc, et al.
Publicado: (2015)

The interactome of 2-Cys peroxiredoxins in Plasmodium falciparum
por: Brandstaedter, Christina, et al.
Publicado: (2019)

Cys-loop receptors on cannabinoids: All high?
por: Schmiedhofer, Philip, et al.
Publicado: (2022)

ROS-Mediated Signalling in Bacteria: Zinc-Containing Cys-X-X-Cys Redox Centres and Iron-Based Oxidative Stress
por: Ortiz de Orué Lucana, Darío, et al.
Publicado: (2012)

Cys−Cys Cross-Linking Shows Contact between the N-Terminus of Lethal Factor and Phe427 of the Anthrax Toxin Pore
por: Janowiak, Blythe E., et al.
Publicado: (2011)

Cysteinyl leukotrienes regulate endothelial cell inflammatory and proliferative signals through CysLT(2) and CysLT(1) receptors
por: Duah, Ernest, et al.
Publicado: (2013)

Role of Cys(I)–Cys(III) Disulfide Bond on the Structure and Activity of α-Conotoxins at Human Neuronal Nicotinic Acetylcholine Receptors
por: Tabassum, Nargis, et al.
Publicado: (2017)

Cannot write session to /tmp/vufind_sessions/sess_a62l7os8ea4lmceqbvs543slde